Such a configuration 'might' work if the VTOL drives on the wings could provide say 0.2G constant acceleration in deep space, making the ship a vertical torchship with moon-like pseudo-gravity. I assume that torchships (constant acceleration to midpoint and deceleration to destination) are beyond 2300AD 'hard science', but I wanted to defend the plausibility of the deep-space aircraft layout for other non-'artificial gravity' applications.
Obviously, the only advantage over a more traditional design would be aerobraking and atmospheric flight - requiring a very specific pair of worlds at either end of the route to justify the expense and complexity of an airframe.

