I use Fractal Terrains for that purpose, but the public versions only do basic landforms and rivers at this point, no lines or text or symbols. The coastlines and river systems in FT, for example, show an appropriate level of detail for the current zoom level. FT3 can do exports for CC3 to allow for additional annotations beyond the basic level.

If you want to use FT for basic roughing-in to get regional items in the correct places, you can sketch in the desired landforms as climate types. FT has the ability to do useful reprojection to get regional area maps with different amounts and kinds of distortions than the whole-world map.

http://www.ridgenet.net/~jslayton/cshelf/index.html shows a way that world-to-regional mapping can be accomplished in Wilbur, but you're pretty much stuck with the basic fractal elements without painting or erosion.