I had to get used to a different layout as I am not at home for one year. Normally I prefer a slightly different setup back home but now it looks like this:

____[Monitor]____
|
_[Keyboard][Mouse]_
|
______[Tablet]______
|
______[Moe (°.°)]_____


I reach the Keyboard easily with my elbows situated left and right to the tablet (usually the pen is behind my right ear ),
the center of the screen is the center of the tablet is the center of the Moe.