My desktop setup is very much like Ravells - except my monitors are ahead and to the right (the way you say you want it set up). I have a keyboard shelf that pulls out under the desk, that's where I keep the tablet and mouse (usually I use the one on the tablet), then reach up to use the keyboard.

When I'm using the laptop at the dining room table I use the tablet directly in front of the keyboard (square), no mouse, just the pen. If I'm sitting at the couch I keep the laptop on the tray in front of me and the tablet in my lap. No angles, though I can deal with it if need be (not so much now that I was able to justify upgrading to cs5 and can rotate the canvas on a whim)