My computer table has a separate shelf underneath the main table for the keyboard, which makes it easy just to roll it out of the way/roll it back out, allowing me to leave my tablet right in front on the main table surface. I'm right handed, so when I first got my tablet I tried angling it to the left slightly, thinking that would be more ergonomic, but through trial and error, I've found that for me, having it directly aligned with the monitor actually does work better, with the mouse to the right of the tablet.